Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2

被引：24

作者：

Feroci, M

Inesi, A

Palombi, L

Sotgiu, G

机构：

[1] Univ Roma La Sapienza, Dipartimento Ingn Chim Mat Mat Prime & Met, I-00161 Rome, Italy

[2] Univ Laquila, Dipartimento Chim Ingn Chim & Mat, I-67040 Laquila, Italy

[3] Univ Roma Tre, Dipartimento Ingn Elettron, I-00146 Rome, Italy

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 05期

关键词：

D O I：

10.1021/jo016323a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.

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页码：1719 / 1721

页数：3

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