Flinderoles A-C: Antimalarial Bis-indole Alkaloids from Flindersia Species

被引：212

作者：

Fernandez, Liza S. ^{[1
,2
]}

Buchanan, Malcolm S. ^{[1
]}

Carroll, Anthony R. ^{[1
]}

Feng, Yun Jiang ^{[1
]}

Quinn, Ronald J. ^{[1
]}

Avery, Vicky M. ^{[1
,2
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Griffith Med Res Coll, Herston, Qld 4006, Australia

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 02期

关键词：

D O I：

10.1021/ol802506n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC50 values between 0.15-1.42 mu M. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.

引用

页码：329 / 332

页数：4

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