Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy

被引：30

作者：

Qin, Qiong ^{[1
]}

Patil, Kiran A. ^{[3
]}

Gronert, Karsten ^{[2
]}

Sharma, Sansar C. ^{[1
]}

机构：

[1] New York Med Coll, Dept Cell Biol & Anat & Ophthalmol, Valhalla, NY 10595 USA

[2] Univ Calif Berkeley, Sch Optometry, Ctr Eye Dis & Dev, Berkeley, CA 94720 USA

[3] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2008年 / 79卷 / 06期

关键词：

Retinal ganglion cell; Docosahexaenoic acid; 12/15-Lipoxygenase;

D O I：

10.1016/j.plefa.2008.09.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuroprotectin D1 (NPD1), a docosahexaenoic acid-derived autacoid, is an enclogenous neuroprotective and anti-inflammatory mediator that is generated in the retina and brain. The effects of exogenous NPD1 on retinal ganglion cell (RGC) apoptosis and the role of 12/15-lipoxygenase (Alox15) in retina were evaluated after optic nerve transection (ONT). Treatment with NPD1 was associated with significant protection against RGC death. The percentage of RGC survival in NPD1-treated group was 30% at 2 weeks after ONT as compared with 12% of RGC survival in the ONT group without treatment. Endogenous NPD1 was a predominant lipid autocoid in uninjured and axotomized retinas. Alox15 mRNA expression was upregulated in retinas following ONT suggesting that amplification of 12/15lipoxygenase (12/15-LOX) may represent a neuroprotective response in the rat retina. The density of RGCs was higher in the normal retina of 12/15-LOX-deficient mice as compared with congenic controls. Hence, the resident NPD1 has a potential role in the physiological and pathophysiological responses of the retina. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：201 / 207

页数：7

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