The selectivity of autophagy and its role in cell death and survival

被引：124

作者：

Yu, Li ^{[1
]}

Strandberg, Lindsey ^{[1
]}

Lenardo, Michael J. ^{[1
]}

机构：

[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA

来源：

AUTOPHAGY | 2008年 / 4卷 / 05期

关键词：

selectivity; autophagy; macroautophagy; necrosis; nonapoptotic cell death;

D O I：

10.4161/auto.5902

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is a cellular process whose primary function is to degrade long-lived proteins and recycle cellular components. Beside macroautophagy, there are several forms of selective autophagy, including chaperone-mediated autophagy (CMA), cytoplasm to vacuole targeting (Cvt), pexophagy and mitophagy. In this review, we summarize what is currently known about selective autophagy, and discuss its role in cell death and survival. We also discuss possible mechanisms underlying the selectivity of macroautophagy.

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收藏

页码：567 / 573

页数：7

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