Macrophages in host defense against Histoplasma capsulatum

被引：77

作者：

Newman, SL ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Div Infect Dis, Cincinnati, OH 45267 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(98)01431-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.

引用

页码：67 / 71

页数：5

共 44 条

[1]

Bonecini-Almeida MG, 1998, J IMMUNOL, V160, P4490

[2] ROLE OF THE ADHERENCE-PROMOTING RECEPTORS, CR3, LFA-1, AND P150,95, IN BINDING OF HISTOPLASMA-CAPSULATUM BY HUMAN MACROPHAGES [J].

BULLOCK, WE ;

WRIGHT, SD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (01) :195-210

[3] KILLING OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY REACTIVE NITROGEN INTERMEDIATES PRODUCED BY ACTIVATED MURINE MACROPHAGES [J].

CHAN, J ;

XING, Y ;

MAGLIOZZO, RS ;

BLOOM, BR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1111-1122

[4] DISSEMINATED TUBERCULOSIS IN INTERFERON-GAMMA GENE-DISRUPTED MICE [J].

COOPER, AM ;

DALTON, DK ;

STEWART, TA ;

GRIFFIN, JP ;

RUSSELL, DG ;

ORME, IM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2243-2247

[5] PH AND THE RECYCLING OF TRANSFERRIN DURING RECEPTOR-MEDIATED ENDOCYTOSIS [J].

DAUTRYVARSAT, A ;

CIECHANOVER, A ;

LODISH, HF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2258-2262

[6]

DEEPE GS, 1992, INFLAMMATION BASIC P, P943

[7] HISTOPLASMA-CAPSULATUM MODULATES THE ACIDIFICATION OF PHAGOLYSOSOMES [J].

EISSENBERG, LG ;

GOLDMAN, WE ;

SCHLESINGER, PH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1605-1611

[8] PHAGOSOME-LYSOSOME FUSION IN P388D1 MACROPHAGES INFECTED WITH HISTOPLASMA-CAPSULATUM [J].

EISSENBERG, LG ;

SCHLESINGER, PH ;

GOLDMAN, WE .

JOURNAL OF LEUKOCYTE BIOLOGY, 1988, 43 (06) :483-491

[9] HISTOPLASMA-CAPSULATUM FAILS TO TRIGGER RELEASE OF SUPEROXIDE FROM MACROPHAGES [J].

EISSENBERG, LG ;

GOLDMAN, WE .

INFECTION AND IMMUNITY, 1987, 55 (01) :29-34

[10] THE INTRACELLULAR FATE OF HISTOPLASMA-CAPSULATUM IN HUMAN MACROPHAGES IS UNAFFECTED BY RECOMBINANT HUMAN INTERFERON-GAMMA [J].

FLEISCHMANN, J ;

WUHSIEH, B ;

HOWARD, DH .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (01) :143-145

← 1 2 3 4 5 →