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Regulation and pro-inflammatory function of interleukin-17 family cytokines

被引：96
作者：
Dong, Chen [1 ]
机构：
[1] Univ Texas Houston, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA
来源：
IMMUNOLOGICAL REVIEWS | 2008年 / 226卷
基金：
美国国家卫生研究院;
关键词：
IL-17; IL-17F; IL-25; inflammation; helper T cells; autoimmune diseases;
D O I：
10.1111/j.1600-065X.2008.00709.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The interleukin-17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4(+) helper T cells and play critical function in inflammation and autoimmunity. IL-17E, also called IL-25, has been associated with allergic responses. Here, I summarize recent work by my laboratory as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.
引用
收藏
页码：80 / 86
页数：7
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