Balancing supramolecular reagents for reliable formation of co-crystals

被引：68

作者：

Aakeröy, CB ^{[1
]}

Desper, J ^{[1
]}

Scott, BMT ^{[1
]}

机构：

[1] Kansas State Univ, Dept Chem, Manhattan, KS 66506 USA

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 13期

关键词：

D O I：

10.1039/b517118k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The rational design and synthesis of a supramolecular reagent (SR) composed of two distinct hydrogen bonding sites (pyrazole-benzamide), and four co-crystals resulting from reactions between this SR and a variety of carboxylic acids are described; the observed primary intermolecular interaction is consistent and predictable in each case.

引用

页码：1445 / 1447

页数：3

共 21 条

[1] Supramolecular reagents:: versatile tools for non-covalent synthesis [J].

Aakeröy, CB ;

Desper, J ;

Urbina, JF .

CHEMICAL COMMUNICATIONS, 2005, (22) :2820-2822

[2] Is conformational flexibility in a supramolecular reagent advantageous for high-yielding co-crystallization reactions? [J].

Aakeröy, CB ;

Desper, J ;

Urbina, JF .

CRYSTENGCOMM, 2005, 7 :193-201

[3] Building co-crystals with molecular sense and supramolecular sensibility [J].

Aakeröy, CB ;

Salmon, DJ .

CRYSTENGCOMM, 2005, 7 :439-448

[4] A high-yielding supramolecular reaction [J].

Aakeröy, CB ;

Beatty, AM ;

Helfrich, BA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (48) :14425-14432

[5]

Aakeröy CB, 2001, ANGEW CHEM INT EDIT, V40, P3240, DOI 10.1002/1521-3773(20010903)40:17<3240::AID-ANIE3240>3.0.CO

[6]

2-X

[7] Crystal engineering of the composition of pharmaceutical phases.: Do pharmaceutical co-crystals represent a new path to improved medicines? [J].

Almarsson, Ö ;

Zaworotko, MJ .

CHEMICAL COMMUNICATIONS, 2004, (17) :1889-1896

[8] Three-component carboxylic acid-bipyridine lattice inclusion host. Supramolecular synthesis of ternary cocrystals [J].

Bhogala, BR ;

Basavoju, S ;

Nangia, A .

CRYSTAL GROWTH & DESIGN, 2005, 5 (05) :1683-1686

[9] Making crystals from crystals: a green route to crystal engineering and polymorphism [J].

Braga, D ;

Grepioni, F .

CHEMICAL COMMUNICATIONS, 2005, (29) :3635-3645

[10] Utility and synthetic uses of Mannich reaction: An efficient route for synthesis of thiadiazino-[1,3,5][3,2-a]benzimidazoles [J].

El-Wareth, A ;

Sarhan, AO ;

Abdel-Hafez, SH ;

El-Sherief, H ;

Aboel-Fadl, T .

SYNTHETIC COMMUNICATIONS, 2006, 36 (08) :987-996

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