Dendritic folate rosettes as ion channels in lipid bilayers

被引：109

作者：

Sakai, N ^{[1
]}

Kamikawa, Y

Nishii, M

Matsuoka, T

Kato, T

Matile, S

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

[2] Univ Tokyo, Sch Engn, Dept Chem & Biotechnol, Bunkyo Ku, Tokyo 1138656, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 07期

关键词：

D O I：

10.1021/ja058157k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self-assembly of folate dendrimers into π-stacked supramolecular rosettes is shown to produce ion channels in planar and spherical lipid bilayer membranes. The found ion channels are small, quite homogeneous, long-lived, ohmic, cation selective (Eisenman I), and blockable by the permeant cation. Copyright © 2006 American Chemical Society.

引用

页码：2218 / 2219

页数：2

共 26 条

[1] Synthetic membrane transporters [J].

Boon, JM ;

Smith, BD .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (06) :749-756

[2] SELF-RECOGNITION AND SELF-ASSEMBLY OF FOLIC-ACID SALTS - COLUMNAR LIQUID-CRYSTALLINE POLYMORPHISM AND THE COLUMN GROWTH-PROCESS [J].

CIUCHI, F ;

DINICOLA, G ;

FRANZ, H ;

GOTTARELLI, G ;

MARIANI, P ;

BOSSI, MGP ;

SPADA, GP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (16) :7064-7071

[3] G-quartets 40 years later:: From 5′-GMP to molecular biology and supramolecular chemistry [J].

Davis, JT .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (06) :668-698

[4] IONIC SELECTIVITY REVISITED - THE ROLE OF KINETIC AND EQUILIBRIUM PROCESSES IN ION PERMEATION THROUGH CHANNELS [J].

EISENMAN, G ;

HORN, R .

JOURNAL OF MEMBRANE BIOLOGY, 1983, 76 (03) :197-225

[5] Toward artificial ion channels: A lipophilic G-quadruplex [J].

Forman, SL ;

Fettinger, JC ;

Pieraccini, S ;

Gottareli, G ;

Davis, JT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (17) :4060-4067

[6] Membrane activity of isophthalic acid derivatives:: Ion channel formation by a low molecular weight compound [J].

Fyles, TM ;

Knoy, R ;

Müllen, K ;

Sieffert, M .

LANGMUIR, 2001, 17 (21) :6669-6674

[7] Dynamic sol-gel interconversion by reversible cation binding and release in G-quartet-based supramolecular polymers [J].

Ghoussoub, A ;

Lehn, JM .

CHEMICAL COMMUNICATIONS, 2005, (46) :5763-5765

[8] Synthetic models of cation-conducting channels [J].

Gokel, GW ;

Mukhopadhyay, A .

CHEMICAL SOCIETY REVIEWS, 2001, 30 (05) :274-286

[9] Synthetic multifunctional pores that open and close in response to chemical stimulation [J].

Gorteau, V ;

Bollot, G ;

Mareda, J ;

Pasini, D ;

Tran, DH ;

Lazar, AN ;

Coleman, AW ;

Sakai, N ;

Matile, S .

BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (17) :5171-5180

[10]

Hille B, 2001, IONIC CHANNELS EXCIT

← 1 2 3 →