Field studies were conducted to determine the effect of nitrogen (N) and phosphorus (P) fertilizer sources and placement configurations on spring wheat growth, yield and quality. Different standard and experimental N and P sources at two rates and in different placement methods provided 32 fertilizer treatments at three locations. Banding of N and P together resulted in the greatest yields. Of the fertilizer combinations where N and P were applied separately, only broadcast N with deep banded P gave similar yields to N and P together. Banding fertilizer with the seed at these levels damaged seedling growth and limited yield. Elevated protein levels, when found, were likely due to lower yields and subsequent concentration of N in grain protein. Careful consideration of fertilizer rate, source and placement strategies to optimize production and water utilization are essential in dryland environments.