Identification and characterisation of constitutional chromosome abnormalities using arrays of bacterial artificial chromosomes

被引：32

作者：

Cowell, JK ^{[1
]}

Wang, YD ^{[1
]}

Head, K ^{[1
]}

Conroy, J ^{[1
]}

McQuaid, D ^{[1
]}

Nowak, NJ ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 04期

关键词：

array-CGH; chromosome deletion; cancer syndromes; BACs;

D O I：

10.1038/sj.bjc.6601588

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Constitutional chromosome deletions and duplications frequently predispose to the development of a wide variety of cancers. We have developed a microarray of 6000 bacterial artificial chromosomes for array-based comparative genomic hybridisation, which provides an average resolution of 750 kb across the human genome. Using these arrays, subtle gains and losses of chromosome regions can be detected in constitutional cells, following a single overnight hybridisation. In this report, we demonstrate the efficiency of this procedure in identifying constitutional deletions and duplications associated with predisposition to retinoblastoma, Wilms tumour and Beckwith-Wiedemann syndrome.

引用

页码：860 / 865

页数：6

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