Is RNA Interference a Physiologically Relevant Innate Antiviral Immune Response in Mammals?

被引：101

作者：

Cullen, Bryan R. ^{[1
,2
]}

Cherry, Sara ^{[3
]}

tenOever, Benjamin R. ^{[4
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Ctr Virol, Durham, NC 27710 USA

[3] Univ Penn, Sch Med, Penn Genome Frontiers Inst, Dept Microbiol, Philadelphia, PA 19104 USA

[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

来源：

CELL HOST & MICROBE | 2013年 / 14卷 / 04期

关键词：

DOUBLE-STRANDED-RNA; INFLUENZA-A VIRUS; GENE-EXPRESSION; CELLS; SUPPRESSION; MICRORNAS; MECHANISM; OOCYTES;

D O I：

10.1016/j.chom.2013.09.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

While RNA interference (RNAi) functions as an antiviral response in plants, nematodes, and arthropods, a similar antiviral role in mammals has remained controversial. Three recent papers provide evidence that either favors or challenges this hypothesis. Here, we discuss these new findings in the context of previous research.

引用

页码：374 / 378

页数：5

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