Minimal access surgery for cholelithiasis induces an attenuated acute phase response

被引：39

作者：

Bruce, DM ^{[1
]}

Smith, M ^{[1
]}

Walker, CBJ ^{[1
]}

Heys, SD ^{[1
]}

Binnie, NR ^{[1
]}

Gough, DB ^{[1
]}

Broom, J ^{[1
]}

Eremin, O ^{[1
]}

机构：

[1] Univ Aberdeen, Dept Clin Biochem, Aberdeen, Scotland

来源：

AMERICAN JOURNAL OF SURGERY | 1999年 / 178卷 / 03期

关键词：

D O I：

10.1016/S0002-9610(99)00160-9

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Some benefits of laparoscopic (LC) and minilaparotomy (NIC) cholecystectomy may reflect attenuation of the acute phase response. The authors examined components of this response. METHODS: Patients were randomized to LC (n = 11) or MC (n = II). C-reactive protein (CRP), alpha-1-antitrypsin (AAT), retinol-binding protein (RBP), transferrin, and albumin were measured preoperatively and on postoperative days 1, 2, 4, and 7. Interleukin-1 receptor antagonist (IL-1ra), IL-6, and tumor necrosis factor (TNF-alpha) were measured more frequently perioperatively. Peak expiratory flow rate, forced expiratory volume in 1 second, and forced vital capacity were measured daily. RESULTS: The IL-6 increase was more persistent and marked in the MC patients from hour 8 to day 7 postoperatively (P < 0.05). Alterations in CRP, AAT, and albumin were similar, Postoperative deficits of respiratory function correlated with the magnitude of acute phase protein alteration. CONCLUSIONS: Minimal access surgery induces an acute phase response that is less prominent after a laparoscopic technique. (C) 1999 by Excerpta Medica, Inc.

引用

页码：232 / 234

页数：3

共 5 条

[1]

DUBOIS F, 1982, NOUV PRESSE MED, V11, P1139

[2] REDUCED POSTOPERATIVE HOSPITALIZATION AFTER LAPAROSCOPIC CHOLECYSTECTOMY [J].