Antiviral and immunoregulatory effect of a novel exopolysaccharide from a marine thermotolerant Bacillus licheniformis

被引：142

作者：

Arena, A

Maugeri, TL

Pavone, B

Iannello, D

Gugliandolo, C

Bisignano, G

机构：

[1] Fac Med, Microbiol Unit, Dept Surg Sci, I-98125 Messina, Italy

[2] Univ Messina, Dept Anim Biol & Marine Ecol, I-98100 Messina, Italy

[3] Univ Messina, PharmacoBiol Dept, I-98100 Messina, Italy

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2006年 / 6卷 / 01期

关键词：

B; licheniformis; cytokines; exopolysaccharide; HSV-2;

D O I：

10.1016/j.intimp.2005.07.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

EPS-1 is a novel extracellular polysaccharide produced by a strain of thermotolerant Bacillus licheniformis, isolated from a shallow marine hot spring of Vulcano Island (Italy). In this paper, antiviral and immunomodulatory effects of EPS-1 were evaluated. It was found that EPS-1 treatment impaired HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells. Since several cytokines modulate the immune response to viruses, Th1- and Th2-type cytokines were assayed in supernatants of PBMC in different experimental conditions. EPS-1 induced IL-12, IFN-gamma, IFN-alpha, TNF-alpha and IL-18, but not IL-4. Thus, the antiviral effect of EPS-1 on PBMC seems to be related to the pattern of cytokines induced. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：8 / 13

页数：6

共 26 条

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