A novel function of peroxiredoxin 1 (Prx-1) in apoptosis signal-regulating kinase 1 (ASK1)-mediated signaling pathway

被引：140

作者：

Kim, So Yong ^{[1
]}

Kim, Tae Jin ^{[1
]}

Lee, Ki-Young ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Dept Mol Cell Biol, Suwon 440746, Gyeonggi Do, South Korea

来源：

FEBS LETTERS | 2008年 / 582卷 / 13期

关键词：

apoptosis; apoptosis signal-regulating kinase 1; peroxiredoxin; 1; hydrogen peroxide; mitogen-activated protein kinase;

D O I：

10.1016/j.febslet.2008.05.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We report a novel function of peroxiredoxin-1 (Prx1) in the ASK1-mediated signaling pathway. Prx-1 interacts with ASK1 via the thioredoxin-binding domain of ASK1 and this interaction is highly inducible by H2O2. However, catalytic mutants of Prx1, C52A, C173A, and C52A/C173A, could not undergo H2O2 inducible interactions, indicating that the redoxsensitive catalytic activity of Prx-1 is required for the interaction with ASK1. Prx-1 overexpression inhibited the activation of ASK1, and resulted in the inhibition of downstream signaling cascades such as the MKK3/6 and p38 pathway. In Prx-1 knockdown cells, ASK1, p38, and JNK were quickly activated, leading to apoptosis in response to H2O2. These findings suggest a negative role of Prx-1 in ASKI-induced apoptosis. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：1913 / 1918

页数：6

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