A longitudinal study of quality of life in advanced non-small cell lung cancer: Cancer and leukemia group B (CALGB) 8931

被引：26

作者：

Herndon, JE

Fleishman, S

Kosty, MP

Green, MR

机构：

[1] LONG ISL JEWISH MED CTR, NEW HYDE PK, NY 11042 USA

[2] SCRIPPS CLIN, LA JOLLA, CA USA

[3] UNIV CALIF SAN DIEGO, SAN DIEGO, CA 92103 USA

来源：

CONTROLLED CLINICAL TRIALS | 1997年 / 18卷 / 04期

关键词：

quality of life; clinical trial; non-small cell lung cancer; hydrazine sulfate;

D O I：

10.1016/0197-2456(96)00116-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A quality of life (QOL) endpoint supplemented standard clinical endpoints of survival, tumor response, and toxicity in a double-blind study conducted by the Cancer and Leukemia Group B (CALGB) where 291 patients with advanced non-small cell lung cancer (NSCLC) were randomly assigned to receive cisplatin/vinblastine with either hydrazine sulfate (HS) or placebo. The difficulties associated with the analysis of the longitudinal QOL data, and the contributions that the QOL endpoint made to the understanding of treatment differences, will be the focus of this paper. (C) Elsevier Science Inc. 1997.

引用

页码：286 / 300

页数：15

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