Anxiety-like behaviors in pre-pubertal rats of the Flinders Sensitive Line (FSL) and Wistar-Kyoto (WKY) animal models of depression

被引:39
作者
Braw, Y
Malkesman, O
Dagan, M
Bercovich, A
Lavi-Avnon, Y
Schroeder, M
Overstreet, DH
Weller, A [1 ]
机构
[1] Bar Ilan Univ, Gonda Goldschmied Multidisciplinary Brain Res Ctr, Dept Psychol, IL-52900 Ramat Gan, Israel
[2] Bar Ilan Univ, Gonda Goldschmied Multidisciplinary Brain Res Ctr, Interdisciplinary Program Brain Sci, Ramat Gan, Israel
[3] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA
基金
以色列科学基金会;
关键词
animal models; depression-anxiety comorbidity; chronic-stress; WKY; FSL;
D O I
10.1016/j.bbr.2005.09.013
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
Animal models have been used in understandina the neuro-biological basis of depression and predicting successful treatment strategies. The current study focused on two genetic models of depression, the Flinder's Sensitive Line (FSL) and Wister-Kyoto (WKY). Our laboratory showed depressive symptomatology in pre-pubertal WKY and FSL rats, and the current study focused on the strains' anxiety-like traits. Since human depression-anxiety comorbidity is very common at Young ages, it is essential to establish whether FSL and WKY pre-pubertal rats also exhibit such comorbidity. In addition, the effect of different rearing environments was studied using a mild chronic-stress condition (limiting available bedding between post-natal days 2-9). Two well-validated tests of anxiety, the open-field and elevated plus-maze, were used on 40-day-old Pups. FSL pups exhibited lower anxiety-like behavior when compared to controls, in traditional open-field and plus-maze measures. A different pattern was observed in the WKY strain, which exhibited heightened anxiety-like behaviours in the FSL strain and affecting WKY's body-weight. Overall, the findings indicate differential expression of anxiety in pre-pubertal rats belonging to the 'depressed' strains. suggesting that these strains may be suitable for modelling different sub-groups of depression at young ages. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:261 / 269
页数:9
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