Breast-feeding and growth factors in preterm newborn infants

被引:49
作者
DiazGomez, NM [1 ]
Domenech, E [1 ]
Barroso, F [1 ]
机构
[1] UNIV LA LAGUNA, HOSP UNIV CANARIAS, DEPT PEDIAT, TENERIFE, CANARY ISLANDS, SPAIN
关键词
human milk; insulin-like growth factors; newborn; nutrition; preterm infants;
D O I
10.1097/00005176-199703000-00016
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: We analyzed the role that nutrition and the insulin-like growth factors IGF-I and IGFBP-3 play on neonatal growth. Methods: Full-term and preterm infants with 1 and 3 weeks of postnatal life (n = 54 and n = 33, respectively) were studied. Anthropmetric variables, daily intake of energy and nutrients, and serum levels of IGF-I and IGFBP-3 were measured. Results: At the first week after birth, preterm infants had lower IGF-I levels than did those in the control group. At the third week of postnatal life, serum IGF-I and IGFBP-3 levels showed a significant increase. Preterm infants born before 33 gestational weeks showed lower IGF-I (p < 0.02) and IGFBP-3 (p < 0.02) levels than those born between 33 and 37 gestational weeks. Preterm infants fed with human milk supplemented with a formula showed higher serum IGF-I levels than those fed exclusively with a mirk formula (mean +/- SEM 48.2 +/- 9.5 mu g/L vs. 25.4 +/- 4.4 mu g/L, p < 0.05). IGF-I and IGFBP-3 were correlated between themselves and with energy and protein intake. Multiple regression analysis confirmed that energy intake and serum IGEBP-3 levels were the most predictable variables with regard to IGF-I levels at neonatal period. Conclusions: These feedings suggest that IGF-I levels during the neonatal periods are influenced by the maturity stage of the newborn, energy intake, and the type of lactation. (C) 1997 Lippincott-Raven Publishers.
引用
收藏
页码:322 / 327
页数:6
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