Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest

被引:40
作者
Louisy, F [1 ]
Schroiff, P [1 ]
Guell, A [1 ]
机构
[1] CTR NATL ETUD SPATIALES,F-31055 TOULOUSE,FRANCE
关键词
weightlessness; leg venous compliance; skeletal muscle mass;
D O I
10.1152/jappl.1997.82.6.1726
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Leg venous hemodynamics [venous distensibility index (VDI), arterial flow index (AFI), half-emptying time (T-1/2)], and leg volumes (LV) were assessed by mercury strain-gauge plethysmography with venous occlusion and volometry, respectively, in seven men before, during, and after 42 days of 6 degrees head-down bed rest. Results showed a high increase in VDI up to day 26 of bed rest (+50% vs. control at day 26, P < 0.05), which tended to subside thereafter (+20% increase vs. control value at day 41, P < 0.05). VDI changes were associated with parallel changes in T-1/2 (+64% vs. control at day 26 of bedrest, P < 0.05, and + 25% vs. control at day 41, P < 0.05) and with a decrease in AFI ( - 49% at day 41 vs. control, P < 0.05). LV continuously decreased throughout bed rest (-13% vs. control at day 41, P < 0.05) but was correlated with VDI only during the first month of bed rest. These: results show that during long-term 6 degrees head-down bed rest alterations of leg venous compliance are associated with impairment of venous emptying capacities and arterial flow Changes in skeletal muscle mass and fluid shifts may account for venous changes during the first month of bed rest but, subsequently, other physiological factors, to be determined, may also be involved in leg venous hemodynamic alterations.
引用
收藏
页码:1726 / 1733
页数:8
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