Lymphostin (LK6-A), a novel immunosuppressant from Streptomyces sp. KY11783: Structural elucidation

被引：29

作者：

Aotani, Y ^{[1
]}

Nagata, H ^{[1
]}

Yoshida, M ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,MACHIDA,TOKYO 194,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 07期

关键词：

D O I：

10.7164/antibiotics.50.543

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lymphostin (LK6-A), a novel immunosuppressant, was isolated from the culture broth of Streptomyces sp. KY11783. Lymphostin showed potent inhibitory activity against the lymphocyte kinase, Lck (p56(lck)). The structure of lymphostin was determined by spectroscopic methods to be a novel tricyclic aromatic alkaloid. A key feature of the structure is the pyrrolo[4,3,2-de]quinoline moiety which is rare among natural products.

引用

页码：543 / 545

页数：3

共 5 条

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