Thermodynamic analysis of biomolecular interactions

被引：178

作者：

Cooper, A ^{[1
]}

机构：

[1] Univ Glasgow, Dept Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(99)00008-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Direct measurement of the thermodynamics of biomolecular interactions is now relatively easy. Interpretation of these thermodynamics in simple molecular terms is not. Recent work shows how the multiplicity of weak noncovalent interactions, and the inevitable enthalpy/entropy compensation that these interactions engender, lead to difficulties in teasing out the different components.

引用

页码：557 / 563

页数：7

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