Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system

被引：24

作者：

Fiore, CE ^{[1
]}

Riccobene, S ^{[1
]}

Mangiafico, R ^{[1
]}

Santoro, F ^{[1
]}

Pennisi, P ^{[1
]}

机构：

[1] Catania Univ OVE, Dept Internal Med, I-95124 Catania, Italy

来源：

OSTEOPOROSIS INTERNATIONAL | 2005年 / 16卷 / 12期

关键词：

hepatitis C-associated osteosclerosis; OPG; RANKL;

D O I：

10.1007/s00198-005-1858-8

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We report a new case of hepatitis C-associated osteosclerosis (HCAO). The clinical presentation of the patient was an acquired deep severe bone pain with increased serum bone alkaline phosphatase activity (up to 12 times the upper limit of normal), and generalized bone sclerosis, temporally related to the hepatitis C-virus (HCV) infection. We documented in this patient an increase of circulating osteoprotegerin (OPG), and a concentration of circulating receptor activator for nuclear factor-kB ligand (RANKL) below the lower limit of the reference range. The observed abnormalities of the OPG/RANKL system may contribute to the maintenance of the positive balance of bone remodeling that characterizes patients with HCAO.

引用

收藏

页码：2180 / 2184

页数：5

相关论文

共 22 条

[1]

A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women [J].

Bekker, PJ ;

Holloway, DL ;

Rasmussen, AS ;

Murphy, R ;

Martin, SW ;

Leese, PT ;

Holmes, GB ;

Dunstan, CR ;

DePaoli, AM .

JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (07) :1059-1066

[2]

DIFFUSE OSTEOSCLEROSIS IN INTRAVENOUS DRUG-ABUSERS [J].

BEYER, HS ;

ANDERSON, Q ;

SHIH, MS ;

PARFITT, AM ;

HEATH, H .

AMERICAN JOURNAL OF MEDICINE, 1993, 95 (06) :660-661

[3]

The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts [J].

Burgess, TL ;

Qian, YX ;

Kaufman, S ;

Ring, BD ;

Van, G ;

Capparelli, C ;

Kelley, M ;

Hsu, HL ;

Boyle, WJ ;

Dunstan, CR ;

Hu, S ;

Lacey, DL .

JOURNAL OF CELL BIOLOGY, 1999, 145 (03) :527-538

[4]

HEPATITIS-C VIRUS - THE MAJOR CAUSATIVE AGENT OF VIRAL NON-A, NON-B HEPATITIS [J].

CHOO, QL ;

WEINER, AJ ;

OVERBY, LR ;

KUO, G ;

HOUGHTON, M ;

BRADLEY, DW .

BRITISH MEDICAL BULLETIN, 1990, 46 (02) :423-441

[5]

Acquired osteosclerosis associated with intravenous drug use and hepatitis C infection [J].

Diamond, T ;

Depczynski, B .

BONE, 1996, 19 (06) :679-683

[6]

Hepatitis c-associated osteosclerosis: An unusual syndrome of acquired osteosclerosis in adults [J].

Hassoun, AAK ;

Nippoldt, TB ;

Tiegs, RD ;

Khosla, S .

AMERICAN JOURNAL OF MEDICINE, 1997, 103 (01) :70-73

[7]

Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-l [J].

Jochum, W ;

David, JP ;

Elliott, C ;

Wutz, A ;

Plenk, H ;

Matsuo, K ;

Wagner, EF .

NATURE MEDICINE, 2000, 6 (09) :980-984

[8]

Use of site-speciftic antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis [J].

Khosla, S ;

Ballard, FJ ;

Conover, CA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (08) :3867-3870

[9]

Minireview: The OPG/RANKL/RANK system [J].

Khosla, S .

ENDOCRINOLOGY, 2001, 142 (12) :5050-5055

[10]

Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis - Potential insights into increasing bone mass in adults [J].

Khosla, S ;

Hassoun, AAK ;

Baker, BK ;

Liu, F ;

Zein, NN ;

Whyte, MP ;

Reasner, CA ;

Nippoldt, TB ;

Tiegs, RD ;

Hintz, RL ;

Conover, CA .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (10) :2165-2173