Altered frequency of T regulatory cells is associated with disability status in relapsing-remitting multiple sclerosis patients

被引：30

作者：

Bjerg, Lasse ^{[1
]}

Brosbol-Ravnborg, Anne ^{[1
]}

Torring, Caroline ^{[1
,2
]}

Dige, Anders ^{[3
]}

Bundgaard, Bettina ^{[1
]}

Petersen, Thor ^{[2
]}

Hollsberg, Per ^{[1
,4
]}

机构：

[1] Aarhus Univ, Dept Biomed, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ Hosp, Dept Neurol, DK-8000 Aarhus, Denmark

[3] Aarhus Univ Hosp, Gastroimmuno Res Lab, Dept Med 5, DK-8000 Aarhus, Denmark

[4] Aarhus Univ Hosp, Danish Neurosci Ctr, DK-8000 Aarhus, Denmark

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 249卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

T regulatory cells; Relapsing-remitting multiple sclerosis; Foxp3; EDSS; EPSTEIN-BARR-VIRUS; FOXP3; EXPRESSION; SUPPRESSIVE FUNCTION; BRAIN; HOMEOSTASIS; INFECTION; PROTEIN; LEVEL; REG;

D O I：

10.1016/j.jneuroim.2012.04.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A perturbed immunoregulation may be part of the pathogenesis of relapsing-remitting multiple sclerosis (RRMS). In this study, we demonstrate a dichotomy within the frequency of Treg among newly diagnosed RRMS patients but not in healthy controls. A group of RRMS patients was characterized by a significantly lower percentage of Treg cells than that of their matched, healthy controls, and this was inversely correlated with their score on the expanded disability status scale (EDSS). Since the EDSS reflected severity of the last attack, this study demonstrates a correlation between low frequency of Treg and severity of clinical disease in RRMS. (C) 2012 Elsevier B.V. All rights reserved.

引用

收藏

页码：76 / 82

页数：7

相关论文

共 35 条

[1] Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production [J].

Allan, Sarah E. ;

Crome, Sarah Q. ;

Crellin, Natasha K. ;

Passerini, Laura ;

Steiner, Theodore S. ;

Bacchetta, Rosa ;

Roncarolo, Maria G. ;

Levings, Megan K. .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (04) :345-354

[2] Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look [J].

Aloisi, Francesca ;

Serafini, Barbara ;

Magliozzi, Roberta ;

Howell, Owain W. ;

Reynolds, Richard .

BRAIN, 2010, 133

[3]

ARNASON BGW, 1978, ANN INST PASTEUR IMM, VC129, P159

[4] Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors [J].

Ascherio, Alberto ;

Munger, Kassandra L. .

ANNALS OF NEUROLOGY, 2007, 61 (06) :504-513

[5] CD4+CD25high regulatory cells in human peripheral blood [J].

Baecher-Allan, C ;

Brown, JA ;

Freeman, GJ ;

Hafler, DA .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1245-1253

[6] The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[7] Expression of ectonucleotidase CD39 by Foxp3+ Treg cells:: hydrolysis of extracellular ATP and immune suppression [J].

Borsellino, Giovanna ;

Kleinewietfeld, Markus ;

Di Mitri, Diletta ;

Sternjak, Alexander ;

Diamantini, Adamo ;

Giometto, Raffaella ;

Hoepner, Sabine ;

Centonze, Diego ;

Bernardi, Giorgio ;

Dell'Acqua, Maria Luisa ;

Rossini, Paolo Maria ;

Battistini, Luca ;

Rotzschke, Olaf ;

Falk, Kirsten .

BLOOD, 2007, 110 (04) :1225-1232

[8] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

[9] The T-cell pool is anergized in patients with multiple sclerosis in remission [J].

Fransson, Moa E. ;

Liljenfeldt, Lina S. E. ;

Fagius, Jan ;

Totterman, Thomas H. ;

Loskog, Angelica S. I. .

IMMUNOLOGY, 2009, 126 (01) :92-101

[10] Validated Protocol for FoxP3 Reveals Increased Expression in Type 1 Diabetes Patients [J].

Grant, Jean ;

Bourcier, Katarzyna ;

Wallace, Stephen ;

Pan, Dalin ;

Conway, Alexis ;

Seyfert-Margolis, Vicki ;

Wallace, Paul K. .

CYTOMETRY PART B-CLINICAL CYTOMETRY, 2009, 76B (02) :69-78

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