Behavioural pharmacology - Breaking the chain of addiction

被引：14

作者：

Aston-Jones, G ^{[1
]}

Druhan, J ^{[1
]}

机构：

[1] Univ Penn, VAMC, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA

来源：

NATURE | 1999年 / 400卷 / 6742期

关键词：

D O I：

10.1038/22432

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cocaine addicts often find themselves in a cycle of withdrawal and relapse, but a newly developed drug might break this cycle. The drug - known as BP 897 - is a partial agonist for the dopamine D3receptor subtype. In the absence of the neurotransmitter dopamine, BP 897 stimulates the D3receptor. But when cocaine has been taken and levels of dopamine are increased, BP 897 antagonizes the D3receptor.

引用

页码：317 / +

页数：2

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