The synergistic action of ethanol and nerve growth factor in the induction of neuronal nitric oxide synthase

被引：7

作者：

Phung, YT ^{[1
]}

Black, SM ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

来源：

ALCOHOL AND ALCOHOLISM | 1999年 / 34卷 / 04期

关键词：

D O I：

10.1093/alcalc/34.4.506

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Ethanol alone had no effect on neuronal nitric oxide synthase (nNOS) expression in PC12 cells. However, in the presence of nerve growth factor (NGF), nNOS expression was amplified (threefold, P < 0.05), compared to NGF alone. This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.

引用

页码：506 / 510

页数：5

共 13 条

[1]

BEAUGE FJ, 1994, INT SOC BIOM RES ALC

[2]

CHANDLER LJ, 1994, RES SOC ALC MAUI HI

[3] SOMATOSTATIN ENHANCES NERVE GROWTH FACTOR-INDUCED NEURITE OUTGROWTH IN PC12 CELLS [J].

FERRIERO, DM ;

SHELDON, RA ;

MESSING, RO .

DEVELOPMENTAL BRAIN RESEARCH, 1994, 80 (1-2) :13-18

[4]

Hammer Jr. R. P., 1986, ALCOHOL BRAIN DEV, P184

[5] An inhibitory fragment derived from protein kinase C epsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters [J].

Hundle, B ;

McMahon, T ;

Dadgar, J ;

Chen, CH ;

MochlyRosen, D ;

Messing, RO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (23) :15028-15035

[6] INHIBITION OF NITRIC-OXIDE SYNTHESIS IMPAIRS RAPID TOLERANCE TO ETHANOL [J].

KHANNA, JM ;

MORATO, GS ;

SHAH, G ;

CHAU, A ;

KALANT, H .

BRAIN RESEARCH BULLETIN, 1993, 32 (01) :43-47

[7]

KOTKOSKIE LA, 1988, ALCOHOLISM CLIN EXPT, V12, P579

[8]

Messing R O, 1993, Alcohol Alcohol Suppl, V2, P289

[9] ETHANOL ENHANCES GROWTH FACTOR-INDUCED NEURITE FORMATION IN PC12 CELLS [J].

MESSING, RO ;

HENTELEFF, M ;

PARK, JJ .

BRAIN RESEARCH, 1991, 565 (02) :301-311

[10] EFFECTS OF ALCOHOL ON THE GENERATION AND MIGRATION OF CEREBRAL CORTICAL-NEURONS [J].

MILLER, MW .

SCIENCE, 1986, 233 (4770) :1308-1311

← 1 2 →