The Universal Protein Resource (UniProt) 2009

被引：450

作者：

Bairoch, Amos ^{[1
]}

Consortium, UniProt ^{[2
,3
]}

Bougueleret, Lydie

Altairac, Severine

Amendolia, Valeria

Auchincloss, Andrea

Argoud-Puy, Ghislaine

Axelsen, Kristian

Baratin, Delphine

Blatter, Marie-Claude

Boeckmann, Brigitte

Bolleman, Jerven

Bollondi, Laurent

Boutet, Emmanuel

Quintaje, Silvia Braconi

Breuza, Lionel

Bridge, Alan

deCastro, Edouard

Ciapina, Luciane

Coral, Danielle

Coudert, Elisabeth

Cusin, Isabelle

Delbard, Gwennaelle

Dornevil, Dolnide

Roggli, Paula Duek

Duvaud, Severine

Estreicher, Anne

Famiglietti, Livia

Feuermann, Marc

Gehant, Sebastian

Farriol-Mathis, Nathalie

Ferro, Serenella

Gasteiger, Elisabeth

Gateau, Alain

Gerritsen, Vivienne

Gos, Arnaud

Gruaz-Gumowski, Nadine

Hinz, Ursula

Hulo, Chantal

Hulo, Nicolas

James, Janet

Jimenez, Silvia

Jungo, Florence

Junker, Vivien

Kappler, Thomas

Keller, Guillaume

Lachaize, Corinne

Lane-Guermonprez, Lydie

Langendijk-Genevaux, Petra

Lara, Vicente

机构：

[1] Univ Geneva, SIB, Ctr Med Univ, CH-1211 Geneva 4, Switzerland

[2] EBI, EMBL Outstn, Cambridge CB10 1SD, England

[3] Georgetown Univ, Med Ctr, Washington, DC 20007 USA

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

基金：

美国国家卫生研究院;

关键词：

ANNOTATION;

D O I：

10.1093/nar/gkn664

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information that is essential for modern biological research. UniProt is produced by the UniProt Consortium which consists of groups from the European Bioinformatics Institute, the Protein Information Resource and the Swiss Institute of Bioinformatics. The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, a user-friendly UniProt website and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of four major components, each optimized for different uses: the UniProt Archive, the UniProt Knowledge-base, the UniProt Reference Clusters and the UniProt Metagenomic and Environmental Sequence Database. One of the key achievements of the UniProt consortium in 2008 is the completion of the first draft of the complete human proteome in UniProtKB/Swiss-Prot. This manually annotated representation of all currently known human protein-coding genes was made available in UniProt release 14.0 with 20 325 entries. UniProt is updated and distributed every three weeks and can be accessed online for searches or downloaded at www.uniprot.org.

引用

页码：D169 / D174

页数：6

共 11 条

[1]

[Anonymous], ENCY GENETICS GENOMI

[2] Priorities for nucleotide trace, sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database [J].

Cochrane, Guy ;

Akhtar, Ruth ;

Aldebert, Philippe ;

Althorpe, Nicola ;

Baldwin, Alastair ;

Bates, Kirsty ;

Bhattacharyya, Sumit ;

Bonfield, James ;

Bower, Lawrence ;

Browne, Paul ;

Castro, Matias ;

Cox, Tony ;

Demiralp, Fehmi ;

Eberhardt, Ruth ;

Faruque, Nadeem ;

Hoad, Gemma ;

Jang, Mikyung ;

Kulikova, Tamara ;

Labarga, Alberto ;

Leinonen, Rasko ;

Leonard, Steven ;

Lin, Quan ;

Lopez, Rodrigo ;

Lorenc, Dariusz ;

McWilliam, Hamish ;

Mukherjee, Gaurab ;

Nardone, Francesco ;

Plaister, Sheila ;

Robinson, Stephen ;

Sobhany, Siamak ;

Vaughan, Robert ;

Wu, Dan ;

Zhu, Weimin ;

Apweiler, Rolf ;

Hubbard, Tim ;

Birney, Ewan .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D5-D12

[3] A novel method for automatic functional annotation of proteins [J].

Fleischmann, W ;

Möller, S ;

Gateau, A ;

Apweiler, R .

BIOINFORMATICS, 1999, 15 (03) :228-233

[4] Ensembl 2008 [J].

Flicek, P. ;

Aken, B. L. ;

Beal, K. ;

Ballester, B. ;

Caccamo, M. ;

Chen, Y. ;

Clarke, L. ;

Coates, G. ;

Cunningham, F. ;

Cutts, T. ;

Down, T. ;

Dyer, S. C. ;

Eyre, T. ;

Fitzgerald, S. ;

Fernandez-Banet, J. ;

Graf, S. ;

Haider, S. ;

Hammond, M. ;

Holland, R. ;

Howe, K. L. ;

Howe, K. ;

Johnson, N. ;

Jenkinson, A. ;

Kahari, A. ;

Keefe, D. ;

Kokocinski, F. ;

Kulesha, E. ;

Lawson, D. ;

Longden, I. ;

Megy, K. ;

Meidl, P. ;

Overduin, B. ;

Parker, A. ;

Pritchard, B. ;

Prlic, A. ;

Rice, S. ;

Rios, D. ;

Schuster, M. ;

Sealy, I. ;

Slater, G. ;

Smedley, D. ;

Spudich, G. ;

Trevanion, S. ;

Vilella, A. J. ;

Vogel, J. ;

White, S. ;

Wood, M. ;

Birney, E. ;

Cox, T. ;

Curwen, V. .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D707-D714

[5] Automated annotation of microbial proteomes in SWISS-PROT [J].

Gattiker, A ;

Michoud, K ;

Rivoire, C ;

Auchincloss, AH ;

Coudert, E ;

Lima, T ;

Kersey, P ;

Pagni, M ;

Sigrist, CJA ;

Lachaize, C ;

Veuthey, AL ;

Gasteiger, E ;

Bairoch, A .

COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2003, 27 (01) :49-58

[6] Gene Ontology annotations at SGD: new data sources and annotation methods [J].

Hong, Eurie L. ;

Balakrishnan, Rama ;

Dong, Qing ;

Christie, Karen R. ;

Park, Julie ;

Binkley, Gail ;

Costanzo, Maria C. ;

Dwight, Selina S. ;

Engel, Stacia R. ;

Fisk, Dianna G. ;

Hirschman, Jodi E. ;

Hitz, Benjamin C. ;

Krieger, Cynthia J. ;

Livstone, Michael S. ;

Miyasato, Stuart R. ;

Nash, Robert S. ;

Oughtred, Rose ;

Skrzypek, Marek S. ;

Weng, Shuai ;

Wong, Edith D. ;

Zhu, Kathy K. ;

Dolinski, Kara ;

Botstein, David ;

Cherry, J. Michael .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D577-D581

[7] UniProt archive [J].

Leinonen, R ;

Diez, FG ;

Binns, D ;

Fleischmann, W ;

Lopez, R ;

Apweiler, R .

BIOINFORMATICS, 2004, 20 (17) :3236-3237

[8] UniRef: comprehensive and non-redundant UniProt reference clusters [J].

Suzek, Baris E. ;

Huang, Hongzhan ;

McGarvey, Peter ;

Mazumder, Raja ;

Wu, Cathy H. .

BIOINFORMATICS, 2007, 23 (10) :1282-1288

[9] The Arabidopsis Information Resource (TAIR): gene structure and function annotation [J].

Swarbreck, David ;

Wilks, Christopher ;

Lamesch, Philippe ;

Berardini, Tanya Z. ;

Garcia-Hernandez, Margarita ;

Foerster, Hartmut ;

Li, Donghui ;

Meyer, Tom ;

Muller, Robert ;

Ploetz, Larry ;

Radenbaugh, Amie ;

Singh, Shanker ;

Swing, Vanessa ;

Tissier, Christophe ;

Zhang, Peifen ;

Huala, Eva .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D1009-D1014

[10] Filtering erroneous protein annotation [J].

Wieser, D. ;

Kretschmann, E. ;

Apweiler, R. .

BIOINFORMATICS, 2004, 20 :342-347

← 1 2 →