Induction and suppression of RNA silencing by an animal virus

被引：655

作者：

Li, HW

Li, WX

Ding, SW ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Plant Pathol, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Ctr Plant Cell Biol, Riverside, CA 92521 USA

来源：

SCIENCE | 2002年 / 296卷 / 5571期

关键词：

D O I：

10.1126/science.1070948

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.

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收藏

页码：1319 / 1321

页数：3

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