Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms

被引：54

作者：

deMello, CF ^{[1
]}

Begnini, J ^{[1
]}

JimenezBernal, RE ^{[1
]}

Rubin, MA ^{[1
]}

deBastiani, J ^{[1
]}

daCosta, EM ^{[1
]}

Wajner, M ^{[1
]}

机构：

[1] UNIV FED RIO GRANDE SUL,INST BIOCIENCIAS,DEPT BIOQUIM,BR-90050170 PORTO ALEGRE,RS,BRAZIL

来源：

BRAIN RESEARCH | 1996年 / 721卷 / 1-2期

关键词：

methylmalonic acid; organic acidemia; neurotoxicity; open field; convulsion; seizure; striatum; excitotoxicity; rotational behavior;

D O I：

10.1016/0006-8993(96)00117-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of intrastriatal administration of methylmalonic acid (MMA), a metabolite that accumulates in methylmalonic aciduria, on behavior of adult male Wistar rats was investigated. After cannula placing, rats received unilateral intrastriatal injections of MMA (buffered to pH 7.4 with NaOH) or NaCl. MMA induced rotational behavior toward the contralateral side of injection and clonic convulsions ill a dose-dependent manner. Rotational behavior rind convulsions were prevented by intrastriatal preadministration of MK-801 and attenuated by preadministration of succinate. This study provides evidence for a participation of NMDA receptors in the MMA-induced behavioral alterations, where succinate dehydrogenase inhibition seems to have a pivotal role.

引用

页码：120 / 125

页数：6

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