Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach

被引：201

作者：

Lacroix, Isabelle M. E. ^{[1
]}

Li-Chan, Eunice C. Y. ^{[1
]}

机构：

[1] Univ British Columbia, Fac Land & Food Syst, Food Nutr & Hlth Program, Vancouver, BC V6T 1Z4, Canada

来源：

JOURNAL OF FUNCTIONAL FOODS | 2012年 / 4卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Dipeptidyl peptidase (DPP)-IV; Inhibitor; In silico analysis; Dietary protein; Bioactive peptide; AMINOPEPTIDASE-IV; DIPROTIN-A; N-TERMINUS; ENZYME; SURFACE;

D O I：

10.1016/j.jff.2012.01.008

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Synthetic inhibitors against the enzyme dipeptidyl peptidase (DPP)-IV, a serine protease implicated in the inactivation of incretin hormones, are currently used for the management of type 2 diabetes. The aim of the present study was to evaluate the potential of dietary proteins from various food commodities to serve as precursors of DPP-IV inhibitors by using an in silico approach. A total of 2256 fragments with peptide sequences matching those reported in the literature to present DPP-IV inhibitory activity were found in the 34 proteins that were investigated. Among those, Gly-Ala, Gly-Pro and Pro-Gly were the most frequently occurring sequences. Caseins from cow's milk and collagens from bovine meat and salmon appeared to be the richest potential sources of DPP-IV inhibitors, whereas proteins from oat showed lower occurrence frequency values. This study suggests that dietary proteins could be used for generating DPP-IV inhibitory peptides. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：403 / 422

页数：20

共 38 条

[1]

A COLLAGEN-BINDING GLYCOPROTEIN ON THE SURFACE OF MOUSE FIBROBLASTS IS IDENTIFIED AS DIPEPTIDYL PEPTIDASE-IV [J].