RNA Folding: Thermodynamic and Molecular Descriptions of the Roles of Ions

被引：196

作者：

Draper, David E. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

来源：

BIOPHYSICAL JOURNAL | 2008年 / 95卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1529/biophysj.108.131813

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The stability of a compact RNA tertiary structure is exquisitely sensitive to the concentrations and types of ions that are present. This review discusses the progress that has been made in developing a quantitative understanding of the thermodynamic parameters and molecular detail that underlie this sensitivity, including the nature of the ion atmosphere, the occurrence of specific ion binding sites, and the importance of the ensemble of partially unfolded states from which folding to the native structure occurs.

引用

页码：5489 / 5495

页数：7

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