Solution-phase parallel tetrahydrofuran synthesis with propargyl alcohols and benzylidene-(or alkylidene-)malonates

被引：33

作者：

Cavicchioli, M

Marat, X

Monteiro, N

Hartmann, B

Balme, GV

机构：

[1] Univ Lyon 1, CNRS, UMR 5622, Lab Chim Organ 1, F-69622 Villeurbanne, France

[2] Aventis Cropsci, F-69623 Lyon, France

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 14期

关键词：

solution-phase synthesis; combinatorial chemistry; copper catalysis; tetrahydrofurans;

D O I：

10.1016/S0040-4039(02)00313-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A large array of 3-methylene tetrahydrofurans has been synthesized from propargylic alcohols and activated olefins. The reaction is promoted by copper iodide that is removed at the end of the reaction by simple filtration, affording the desired heterocycles in high yield and purity. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：2609 / 2611

页数：3

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