Adhesion and liquid-liquid phase separation in globular protein solutions

被引：10

作者：

Braun, FN ^{[1
]}

机构：

[1] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

来源：

JOURNAL OF CHEMICAL PHYSICS | 2002年 / 116卷 / 15期

关键词：

D O I：

10.1063/1.1461358

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We derive a form of adhesive interaction between protein globules in solution, developing from the premise that amino-acid residues are able to rearrange around a globule-globule contact. We show in this approach that globules only become adhesive above a certain threshold temperature, which is sensitive to an osmotic modulus characterizing individual globule elasticity. Above the threshold, adhesive strength increases monotonically with temperature, driving a temperature-reversed liquid-liquid phase separation. (C) 2002 American Institute of Physics.

引用

页码：6826 / 6830

页数：5

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