Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir

被引：126

作者：

Collins, Jeffrey M. ^{[1
]}

Raphael, Kara Loren ^{[2
]}

Terry, Charles ^{[2
]}

Cartwright, Emily J. ^{[1
,5
]}

Pillai, Anjana ^{[3
,4
]}

Anania, Frank A. ^{[3
,5
]}

Farley, Monica M. ^{[1
,5
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA 30322 USA

[2] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Med, Div Digest Dis, Atlanta, GA 30322 USA

[4] Emory Univ, Sch Med, Emory Transplant Ctr, Atlanta, GA 30322 USA

[5] Atlanta Vet Affairs Med Ctr, Atlanta, GA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2015年 / 61卷 / 08期

关键词：

HBV/HCV coinfection; HBV reactivation; acute hepatitis; sofosbuvir; simeprevir; CHRONIC INFECTION; RIBAVIRIN; INTERFERON; COINFECTION; THERAPY;

D O I：

10.1093/cid/civ474

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Treatment of hepatitis C virus with potent, interferon-free, direct-acting antiviral regimens with no activity against hepatitis B virus (HBV) may increase the risk for HBV reactivation in coinfected patients. We present 2 cases of HBV reactivation during treatment with an all-oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.

引用

页码：1304 / 1306

页数：3

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