Duration of untreated psychosis and cognitive deterioration in first-episode schizophrenia

被引:130
作者
Amminger, GP
Edwards, J
Brewer, WJ
Harrigan, S
McGorry, PD
机构
[1] Univ Melbourne, Dept Psychiat, EPPIC, MH SKY, Melbourne, Vic 3052, Australia
[2] Univ Hosp Child & Adolescent Neuropsychiat, Vienna, Austria
[3] Univ Melbourne, Cognit Neuropsychiat Unit, Melbourne, Vic, Australia
[4] Univ Melbourne, Schizophrenia Res Unit, Mental Hlth Res Inst Victoria, Melbourne, Vic, Australia
关键词
first-episode schizophrenia; cognition; duration of untreated psychosis;
D O I
10.1016/S0920-9964(01)00278-X
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Cognitive impairment is an important clinical feature in many individuals with schizophrenia. Factors associated with cognitive deficit are not well established, Duration of untreated psychosis (DUP) has recently gained interest as a prognostic factor in schizophrenia. This study reports on the association between DUP and cognitive function. Subjects comprised 42 individuals (30 males, 12 females) who experienced a first-episode of DSM-III-R schizophrenia or schizophreniform disorder. Cognitive function was determined at clinical stabilization using the WAIS-R. An estimate of cognitive deterioration was based on the WAIS-R. subtest profile. Longer DUP. male gender, higher premorbid IQ and younger age at admission independently predicted cognitive deterioration. Poorer performance on Digit Symbol and Comprehension subtests was associated with longer DUP. The findings suggest that untreated psychosis compromises some aspects of cognitive function. Studies investigating the association between DUP and outcome should control for potentially confounding variables. Early treatment of psychosis could help to reduce the prominent cognitive deficit in first-episode schizophrenia. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:223 / 230
页数:8
相关论文
共 39 条
  • [1] Neuropsychological impairment in first-episode and chronic schizophrenic patients
    Albus, M
    Hubmann, W
    Ehrenberg, C
    Forcht, U
    Mohr, F
    Sobizack, N
    Wahlheim, C
    Hecht, S
    [J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1996, 246 (05) : 249 - 255
  • [2] Andreasen N, 1984, SCALE ASSESSMENT NEG
  • [3] Andreasen N, 1984, SCALE ASSESSMENT POS
  • [4] West London first-episode study of schizophrenia - Clinical correlates of duration of untreated psychosis
    Barnes, TRE
    Hutton, SB
    Chapman, MJ
    Mutsatsa, S
    Puri, BK
    Joyce, EM
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 2000, 177 : 207 - 211
  • [5] Basso MR, 1997, NEUROPSY NEUROPSY BE, V10, P107
  • [6] INTELLECTUAL DEFICITS IN 1ST-EPISODE SCHIZOPHRENIA - EVIDENCE FOR PROGRESSIVE DETERIORATION
    BILDER, RM
    LIPSCHUTZBROCH, L
    REITER, G
    GEISLER, SH
    MAYERHOFF, DI
    LIEBERMAN, JA
    [J]. SCHIZOPHRENIA BULLETIN, 1992, 18 (03) : 437 - 448
  • [7] SYMPTOMATIC AND NEUROPSYCHOLOGICAL COMPONENTS OF DEFECT STATES
    BILDER, RM
    MUKHERJEE, S
    RIEDER, RO
    PANDURANGI, AK
    [J]. SCHIZOPHRENIA BULLETIN, 1985, 11 (03) : 409 - 419
  • [8] MEASUREMENT OF PREMORBID ADJUSTMENT IN CHRONIC-SCHIZOPHRENIA
    CANNONSPOOR, HE
    POTKIN, SG
    WYATT, RJ
    [J]. SCHIZOPHRENIA BULLETIN, 1982, 8 (03) : 470 - 484
  • [9] Duration of untreated psychosis and 12-month outcome in first-episode psychosis: the impact of treatment approach
    Carbone, S
    Harrigan, S
    McGorry, PD
    Curry, C
    Elkins, K
    [J]. ACTA PSYCHIATRICA SCANDINAVICA, 1999, 100 (02) : 96 - 104
  • [10] A POWER PRIMER
    COHEN, J
    [J]. PSYCHOLOGICAL BULLETIN, 1992, 112 (01) : 155 - 159