Neuroprotective effects of gonadal steroids on regenerating peripheral motoneurons

被引：81

作者：

Jones, KJ

Brown, TJ

Damaser, M

机构：

[1] Loyola Univ, Stritch Sch Med, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA

[2] Edward Hines Jr VA Hosp, Res & Dev Serv, Hines, IL 60141 USA

[3] Loyola Univ, Stritch Sch Med, Dept Urol, Maywood, IL 60153 USA

来源：

BRAIN RESEARCH REVIEWS | 2001年 / 37卷 / 1-3期

关键词：

testosterone; estradiol; facial nerve; sciatic nerve; pudendal nerve; stress response;

D O I：

10.1016/S0165-0173(01)00107-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this review, the neuroprotective actions of testosterone on three different populations of injured rat peripheral motoneurons, i.e. facial (FMN), spinal (SMN) and pudendal (PMN), will be discussed. We have extrapolated concepts from the neuroendocrine field regarding the trophic effects of gonadal steroids on target neural tissue to the nerve regeneration field. Exogenous administration of testosterone immediately after nerve injury impacts positively on functional recovery through actions mediated by the androgen receptor. The mechanism by which steroidal enhancement of the regenerative properties of injured motoneurons occurs may involve pre-existing androgen receptors, heat shock proteins, and modulation of the cellular stress response. Published by Elsevier Science B.V.

引用

页码：372 / 382

页数：11

共 89 条

[1] ENHANCEMENT OF THE CONDITIONING LESION EFFECT IN RAT SCIATIC MOTOR AXONS AFTER SUPERIMPOSITION OF CONDITIONING AND TEST LESIONS [J].