Microwave-enhanced Goldberg reaction:: a novel route to N-arylpiperazinones and N-arylpiperazinediones

被引：67

作者：

Lange, JHM ^{[1
]}

Hofmeyer, LJF ^{[1
]}

Hout, FAS ^{[1
]}

Osnabrug, SJM ^{[1
]}

Verveer, PC ^{[1
]}

Kruse, CG ^{[1
]}

Feenstra, RW ^{[1
]}

机构：

[1] Solvay Pharmaceut, Res Labs, NL-1380 DA Weesp, Netherlands

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(01)02334-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented microwave-enhanced Goldberg reaction constitutes the key strategic step in the synthesis of N-arylpiperazinones, N-arylpiperazinediones and N-aryl-3,4-dihydroquinolinones. Microwave irradiation greatly accelerates the Goldberg reaction using NMP as solvent. Alkylation at the 3-position of the formed N-aryl-2-piperazinones furnishes new N-aryl-3-alkyl-2-piperazinones, (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1101 / 1104

页数：4

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