Continuous subcutaneous glucose monitoring in diabetic patients - A multicenter analysis

被引:145
作者
Maran, A
Crepaldi, C
Tiengo, A
Grassi, G
Vitali, E
Pagano, G
Bistoni, S
Calabrese, G
Santeusanio, F
Leonetti, F
Ribaudo, M
Di Mario, U
Annuzzi, G
Genovese, S
Riccardi, G
Previti, M
Cucinotta, D
Giorgino, F
Bellomo, A
Giorgino, R
Poscia, A
Varalli, M
机构
[1] Univ Padua, Cattedra Malattie Metab, Dipartimento Med Clin & Sperimentale, I-35123 Padua, Italy
[2] Osped Le Molinette, Dipartimento Med Interna, Turin, Italy
[3] Univ Perugia, Dipartimento Med Interna Sci Endocrine & Metab, I-06100 Perugia, Italy
[4] Univ Roma La Sapienza, Policlin Umberto I, Med Clin 2, Rome, Italy
[5] Univ Naples Federico II, Dipartimento Med Interna & Sperimentale, Naples, Italy
[6] Policlin Univ, Messina, Italy
[7] Univ Bari, Ist Clin Med & Malattle Metab, Bari, Italy
[8] A Menarini Diagnost, Florence, Italy
关键词
D O I
10.2337/diacare.25.2.347
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE- To evaluate the accuracy of a new subcutaneous glucose sensor (Glucoday; A. Menarini Diagnostics) compared with venous blood glucose measurement in type 1 and type 2 diabetic patients. RESEARCH DESIGN - A multicenter study was performed in 70 diabetic patients. A microdialysis fiber was inserted subcutaneously into the periumbelical region arid perfused with a buffer solution. Glucose concentrations in the dialysate were then measured every 3 min by the glucose sensor over a 24-h period, during which nine venous blood samples were also collected throughout the day. RESULTS - Both the insertion of the fiber and the wearing of the device were well tolerated by the patients. Subcutaneous glucose levels were well correlated with venous glucose measurements (r = 0.9, P < 0.001) over a wide range (40-400 mg/dl) for up to 24 calibration. An analysis of 381 data pairs showed a linear relationship between the GlucoDay and serial venous blood glucose levels, and 97% of the data fell in the A and B regions of the error grid analysis. Percentage bias between the GlucoDay and the blood venous levels was -2.0% in the hypoglycemic range (<70 mg/dl), 6.9% in the euglycemic range (70-180 mg/dl), and 11.2% in the hyperglycemic range (>180 mg/dl). CONCLUSIONS- The GlucoDay system demonstrated high reliability and reported values that closely agreed with venous blood glucose measurements. The system was well tolerated and thus constitutes a relatively easy method to monitor glucose excursions in diabetic patients.
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页码:347 / 352
页数:6
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