An angiotensin-I converting enzyme inhibitor from buckwheat (Fagopyrum esculentum Moench) flour

被引：41

作者：

Aoyagi, Y ^{[1
]}

机构：

[1] Kagawa Nutr Univ, Sakado, Saitama 3500288, Japan

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 06期

关键词：

buckwheat; Fagopyrum esculentum; polygonaceae; ACE inhibitor; hypotension; non-protein amino acid; phytosiderophore; nicotianamine; 2 ''-hydroxynicotianamine;

D O I：

10.1016/j.phytochem.2005.12.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A compound that inhibited angiotensin-I converting enzyme (ACE) activity was isolated from buckwheat powder. This compound is thought to be the hydroxy derivative of nicotianamine and its chemical structure is 2"-hydroxynicotianamine. This compound showed a very high inhibitory activity toward ACE, and the IC50 was 0.08 mu M. Only this hydroxy analog was found in buckwheat powder, at about 30 mg/100 g, and no nicotianamine was detected. However, nicotianamine was detected in the buckwheat plant body. 2"-hydroxynicotianamine was also found in other polygonaceous plants. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：618 / 621

页数：4

共 19 条

[1] SPECTROPHOTOMETRIC ASSAY AND PROPERTIES OF ANGIOTENSIN-CONVERTING ENZYME OF RABBIT LUNG [J].