A review of the BSE epidemic in British cattle

被引:7
作者
Donnelly, CA
MaWhinney, S
Anderson, RM
机构
[1] Univ Oxford, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3FY, England
[2] Univ Colorado, Hlth Sci Ctr, Dept Prevent Med & Biometr, Denver, CO 80202 USA
关键词
D O I
10.1046/j.1526-0992.1999.09926.x
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Bovine spongiform encephalopathy (BSE) was first diagnosed in British cattle in 1986. The infectious agents of transmissible spongiform encephalopathy (TSD) diseases are believed to be infectious proteins or prions. They can remain infectious despite exposures to disinfectants, autoclaving, radiation, and ultraviolet light. TSEs affect animals as well as humans and are characterized by progressively severe psychomotor dysfunction and long incubation periods. As of August 27, 1999, 175,404 cases of BSE have been confirmed in Great Britain with 1,787 additional confirmed cases in Northern ireland las of August 31, 1999). Mathematical and statistical analyses of the BSE epidemic data suggest that the incidence of BSE in Great Britain and Northern Ireland will continue its rapid decline. Evidence relating to maternal and horizontal transmission of BSE is discussed. Public concern remains focused on the probable link between BSE infection in cattle and a new variant of Creutzfeldt-Jakob Disease (vCJD) in humans, another TSE. Given the long and variable incubation periods associated with TSEs, and a possible genetic component, the eventual magnitude of this human epidemic remains uncertain.
引用
收藏
页码:164 / 173
页数:10
相关论文
共 98 条
  • [1] DOES AGENT OF SCRAPIE REPLICATE WITHOUT NUCLEIC ACID
    ALPER, T
    CRAMP, WA
    HAIG, DA
    CLARKE, MC
    [J]. NATURE, 1967, 214 (5090) : 764 - &
  • [2] Transmission dynamics and epidemiology of BSE in British cattle
    Anderson, RM
    Donnelly, CA
    Ferguson, NM
    Woolhouse, MEJ
    Watt, CJ
    Udy, HJ
    MaWhinney, S
    Dunstan, SP
    Southwood, TRE
    Wilesmith, JW
    Ryan, JBM
    Hoinville, LJ
    Hillerton, JE
    Austin, AR
    Wells, GAH
    [J]. NATURE, 1996, 382 (6594) : 779 - 788
  • [3] BACCHETTI P, 1993, STAT SCI, V8, P82, DOI 10.1214/ss/1177010994
  • [4] Creutzfeldt-Jakob disease and eating squirrel brains
    Berger, JR
    Weisman, E
    Weisman, B
    [J]. LANCET, 1997, 350 (9078) : 642 - 642
  • [5] BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) - THE CURRENT SITUATION AND RESEARCH
    BRADLEY, R
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1991, 7 (05) : 532 - 544
  • [6] BROOKMEYER R, 1986, LANCET, V2, P1320
  • [7] A METHOD FOR OBTAINING SHORT-TERM PROJECTIONS AND LOWER BOUNDS ON THE SIZE OF THE AIDS EPIDEMIC
    BROOKMEYER, R
    GAIL, MH
    [J]. JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1988, 83 (402) : 301 - 308
  • [8] RESISTANCE OF SCRAPIE INFECTIVITY TO STEAM AUTOCLAVING AFTER FORMALDEHYDE FIXATION AND LIMITED SURVIVAL AFTER ASHING AT 360-DEGREES-C - PRACTICAL AND THEORETICAL IMPLICATIONS
    BROWN, P
    LIBERSKI, PP
    WOLFF, A
    GAJDUSEK, DC
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (03) : 467 - 472
  • [9] THE NEW BIOLOGY OF SPONGIFORM ENCEPHALOPATHY - INFECTIOUS AMYLOIDOSES WITH A GENETIC TWIST
    BROWN, P
    GOLDFARB, LG
    GAJDUSEK, DC
    [J]. LANCET, 1991, 337 (8748) : 1019 - 1022
  • [10] FRIENDLY FIRE IN MEDICINE - HORMONES, HOMOGRAFTS, AND CREUTZFELDT-JAKOB DISEASE
    BROWN, P
    PREECE, MA
    WILL, RG
    [J]. LANCET, 1992, 340 (8810) : 24 - 27