Nonalcoholic Fatty Liver Disease Is Associated With Atherosclerosis in Middle-Aged and Elderly Chinese

被引：103

作者：

Huang, Yun ^{[1
,2
]}

Bi, Yufang ^{[1
,2
]}

Xu, Min ^{[1
,2
]}

Ma, Zhimin ^{[1
]}

Xu, Yu ^{[1
,2
]}

Wang, Tiange ^{[1
,2
]}

Li, Mian ^{[1
,2
]}

Liu, Yu ^{[1
]}

Lu, Jieli ^{[1
,2
]}

Chen, Yuhong ^{[1
,2
]}

Huang, Fei ^{[1
]}

Xu, Baihui ^{[1
]}

Zhang, Jie ^{[1
]}

Wang, Weiqing ^{[1
,2
]}

Li, Xiaoying ^{[1
,2
]}

Ning, Guang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Rui Jin Hosp,Sch Med, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Key Lab Endocrine & Metab Dis, Minist Hlth, Rui Jin Hosp,Sch Med,E Inst Shanghai Univ, Shanghai 200025, Peoples R China

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2012年 / 32卷 / 09期

关键词：

atherosclerosis; brachial-ankle pulse wave velocity; carotid intima-media thickness; metabolic syndrome; nonalcoholic fatty liver disease; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; RISK; STEATOHEPATITIS; THICKNESS;

D O I：

10.1161/ATVBAHA.112.252957

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective-To evaluate the associations between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis. Methods and Results-A total of 8632 participants aged >= 40 years from Jiading district, Shanghai, were included in the present study. The presence of NAFLD was evaluated by ultrasonography. Carotid intima-media thickness (CIMT) and brachial-ankle pulse wave velocity (ba-PWV) were measured in each participant. The prevalence of NAFLD was 30.0% in the total population, with 30.3% in men and 29.9% in women, respectively. Subjects with NAFLD had remarkably higher CIMT and ba-PWV compared with those without NAFLD (0.594 +/- 0.105 mm versus 0.578 +/- 0.109 mm, P<0.0001; 1665 +/- 424 cm/s versus 1558 +/- 430 cm/s, P<0.0001). Subjects with both NAFLD and metabolic syndrome had significantly higher CIMT and ba-PWV compared with those with neither or either of these 2 diseases after adjustment for age and sex (all P<0.05). Logistic regressions also revealed that NAFLD conferred 35% and 30% increased odds ratios of elevated CIMT and ba-PWV, independent of conventional risk factors and the presence of metabolic syndrome. Conclusion-NAFLD was associated with elevated CIMT and ba-PWV, independent of conventional cardiovascular disease risk factors and metabolic syndrome. The effects of NAFLD and metabolic syndrome on atherosclerosis might not fully overlap. (Arterioscler Thromb Vasc Biol. 2012;32:2321-2326.)

引用

页码：2321 / 2326

页数：6

共 29 条

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