A search for quantitative trait loci for milk production traits on chromosome 6 in Finnish Ayrshire cattle

被引：89

作者：

Velmala, RJ ^{[1
]}

Vilkki, HJ ^{[1
]}

Elo, KT ^{[1
]}

de Koning, DJ ^{[1
]}

Mäki-Tanila, AV ^{[1
]}

机构：

[1] Agr Res Ctr, Inst Anim Prod, FIN-31600 Jokioinen, Finland

来源：

ANIMAL GENETICS | 1999年 / 30卷 / 02期

关键词：

microsatellite; casein; interval mapping; regression; quantitative trait loci; cattle;

D O I：

10.1046/j.1365-2052.1999.00435.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Cattle chromosome 6 was scanned with 11 markers, ten microsatellites and the casein haplotype, to identify quantitative trait loci (QTLs) affecting the following milk production traits: milk yield, fat percentage, fat yield, protein percentage and protein yield. Twelve Finnish Ayrshire half-sib families with a total of 480 sons were genotyped and used in a granddaughter design. Interval mapping was performed with a multiple-marker regression approach with a one-QTL and a two-QTL model, and the significance threshold values were determined empirically using a permutation test. Across-family analysis with the one-QTL model revealed an effect on protein percentage (P < 0.05) and on milk yield (P < 0.05). The analysis with the two-QTL model identified significant effects (P < 0.05) on protein percentage, milk yield, and fat yield. Comparing these two cases, the results suggest the existence of two QTLs on chromosome 6 with an effect on milk production traits. One of the QTLs was:located around the casein genes. As the other QTL was similar in location and effect to a QTL found previously in Holstein-Friesians, an identity-by-descent approach could be applied to fine map this region.

引用

页码：136 / 143

页数：8

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