Direct on-resin synthesis of peptide-αthiophenylesters for use in native chemical ligation

被引：37

作者：

Bang, D ^{[1
]}

Pentelute, BL

Gates, ZP

Kent, SB

机构：

[1] Univ Chicago, Dept Chem, Inst Biophys Dynam, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 06期

关键词：

D O I：

10.1021/ol052811j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A peptide-(alpha)thiophenylester is a key reactant in native chemical ligation. Preformation of the peptide-(alpha)thiophenylester could be useful for enhancing the ligation reaction. We report the direct on-resin preparation of preformed peptide-(alpha)thiophenylesters using a simple and efficient method. The peptide-(alpha)thiophenylester reacted extremely rapidly with a Cys-peptide when compared to the peptide-(alpha)thioalkylester.

引用

页码：1049 / 1052

页数：4

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