Molecular Pharmacophore Determination of Lipid Lowering Drugs with the Receptor Mapping Method

被引：4

作者：

Ablise, M. ^{[1
,3
]}

Cartier, A. ^{[2
]}

Siest, G. ^{[3
]}

Visvikis, S. ^{[3
]}

Loppinet, V. ^{[3
]}

机构：

[1] Xinjiang Med Univ, Coll Pharm, Urumqi 830054, Peoples R China

[2] Univ Henri Poincare, Fac Sci, UMR 7565, F-54000 Nancy, France

[3] Univ Henri Poincare, Fac Pharm, INSERM 525, F-54000 Nancy, France

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2002年 / 2卷 / 02期

关键词：

molecular modeling; hypolipidemic pharmacophore; EMO and GEOMOS programs; semi-empirical PM3 method; glycyrrhetinic acid derivatives;

D O I：

10.2174/1389557024605528

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hypolipidemic pharmacophoric moieties of statins, fibrates, ACAT inhibitors and beta-sitosterol analog series were identified by computational modeling, and compared with the computed structure of new potential glycyrrhetinic acid derivatives lipid-lowering drugs. Their electronic and geometric domains, similar to those of fibrates, suggest a fibrate -like mechanism matching biochemical data.

引用

页码：97 / 102

页数：6

共 6 条

[1] The regulation of acetyl-CoA carboxylase - A potential target for the action of hypolipidemic agents [J].

Munday, MR ;

Hemingway, CJ .

ADVANCES IN ENZYME REGULATION, VOL 39, 1999, 39 :205-234

[2]

RINALDI D, 1989, QCPE B, V9, P128

[3]

Sorbera L. A., 1998, Drugs of the Future, V23, P712, DOI 10.1358/dof.1998.023.07.466747

[4]

VASILENKO YK, 1982, FARMAKOL TOKSIKOL, V45, P66

[5]

Yoshihiro F., 1997, CLIN DRUG INVEST, V14, P125

[6]

Zakirov U. B., 1996, Eksperimental'naya i Klinicheskaya Farmakologiya, V59, P53

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