Recent and Emerging Anti-Diabetes Targets

被引：83

作者：

Mohler, Michael L. ^{[1
]}

He, Yali ^{[1
]}

Wu, Zhongzhi ^{[1
]}

Hwang, Dong Jin ^{[1
]}

Miller, Duane D. ^{[1
]}

机构：

[1] GTx Inc, Preclin Res & Dev, Memphis, TN 38163 USA

来源：

MEDICINAL RESEARCH REVIEWS | 2009年 / 29卷 / 01期

关键词：

diabetes; diabetes mellitus; metabolic syndrome; atherosclerosis; insulin resistance; dyslipidemia; obesity; anti-diabetic pharmacotherapy; ACTIVATED PROTEIN-KINASE; GLYCOGEN-SYNTHASE KINASE-3; HORMONE-SENSITIVE LIPASE; BETA(3)-ADRENERGIC RECEPTOR AGONISTS; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; MUSCLE INSULIN-RESISTANCE; IN-VITRO CHARACTERIZATION; ORAL ANTIDIABETIC AGENTS; GLUCAGON-LIKE PEPTIDE-1; BETA-CELL DYSFUNCTION;

D O I：

10.1002/med.20142

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diabetes is a disease that affects over 150 million people worldwide for which there are multiple oral and injectable medications. Because of trends in obesity and sedentary lifestyles, diabetes rates in both developed and developing countries are increasing at an alarming rate. Current medications are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination, leaving diabetics susceptible to developing life threatening and debilitating complications such as cardiovascular disease, blindness, kidney complications, and amputations. Consequently, there is a critical need for more potent pharmacotherapies with novel mechanisms of action. A panel of 20 emerging diabetes targets is presented, and small molecule modulators for each target will be discussed. (C) 2008 Wiley Periodicals. Inc. Med Res Rev, 29, No. 1, 125-195, 2009

引用

页码：125 / 195

页数：71

共 328 条

[31] Nateglinide - current and future role in the treatment of patients with type 2 diabetes mellitus [J].

Campbell, IW .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2005, 59 (10) :1218-1228

[32] PDE-10A inhibitors as insulin secretagogues [J].

Cantin, Louis-David ;

Magnuson, Steven ;

Gunn, David ;

Barucci, Nicole ;

Breuhaus, Marina ;

Bullock, William H. ;

Burke, Jennifer ;

Claus, Thomas H. ;

Daly, Michelle ;

DeCarr, Lynn ;

Gore-Willse, Ann ;

Hoover-Litty, Helana ;

Kumarasinghe, Ellalahewage S. ;

Li, Yaxin ;

Liang, Sidney X. ;

Livingston, James N. ;

Lowinger, Timothy ;

MacDougall, Margit ;

Ogutu, Herbert O. ;

Olague, Alan ;

Ott-Morgan, Ronda ;

Schoenleber, Robert W. ;

Tersteegen, Adrian ;

Wickens, Philip ;

Zhang, Zhonghua ;

Zhu, Jian ;

Zhu, Lei ;

Sweet, Laurel J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (10) :2869-2873

[33]

CAPEAU J, 2007, J HEPATOL

[34] Evolution of peroxisome proliferator-activated receptor agonists [J].

Chang, Feng ;

Jaber, Linda A. ;

Berlie, Helen D. ;

O'Connell, Mary Beth .

ANNALS OF PHARMACOTHERAPY, 2007, 41 (06) :973-983

[35] A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis [J].

Chawla, A ;

Boisvert, WA ;

Lee, CH ;

Laffitte, BA ;

Barak, Y ;

Joseph, SB ;

Liao, D ;

Nagy, L ;

Edwards, PA ;

Curtiss, LK ;

Evans, RM ;

Tontonoz, P .

MOLECULAR CELL, 2001, 7 (01) :161-171

[36]

Chawla Paramjith S, 2006, WMJ, V105, P24

[37] Inhibition of fructose-1,6-bisphosphatase by a new class of allosteric effectors [J].

Choe, JY ;

Nelson, SW ;

Arienti, KL ;

Axe, FU ;

Collins, TL ;

Jones, TK ;

Kimmich, RDA ;

Newman, MJ ;

Norvell, K ;

Ripka, WC ;

Romano, SJ ;

Short, KM ;

Slee, DH ;

Fromm, HJ ;

Honzatko, RB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) :51176-51183

[38] A role for β-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release [J].

Chu, Zhi-Liang ;

Jones, Robert M. ;

He, Hongmei ;

Carroll, Chris ;

Gutierrez, Veronica ;

Lucman, Annette ;

Moloney, Molly ;

Gao, Hui ;

Mondala, Helen ;

Bagnol, Didier ;

Unett, David ;

Liang, Yin ;

Demarest, Keith ;

Semple, Graeme ;

Behan, Dominic P. ;

Leonard, James .

ENDOCRINOLOGY, 2007, 148 (06) :2601-2609

[39] Glucocorticoid receptor antagonists [J].

Clark, Robin D. .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2008, 8 (09) :813-838

[40] Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose [J].

Claus, TH ;

Lowe, DB ;

Liang, Y ;

Salhanick, AI ;

Lubeski, CK ;

Yang, L ;

Lemoine, L ;

Zhu, J ;

Clairmont, KB .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 315 (03) :1396-1402

← 1 2 3 4 5 6 7 8 9 10 →