Neuropsychological abnormalities in first degree relatives of patients with familial Parkinson's disease

被引:27
作者
Dujardin, K [1 ]
Duhamel, A
Becquet, E
Grunberg, C
Defebvre, L
Destee, A
机构
[1] Ctr Hosp Reg & Univ Lille, Hop R Salengro, Neurol Clin, F-59037 Lille, France
[2] Univ Lille 3, UFR Psychol, F-59653 Villeneuve Dascq, France
[3] Univ Lille 2, Fac Med, CERIM, F-59037 Lille, France
关键词
Parkinson's disease; executive function; risk factors;
D O I
10.1136/jnnp.67.3.323
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective-To investigate the cognitive profile of first degree relatives of patients with familial Parkinson's disease to determine whether these subjects presented signs of neuropsychological dysfunction compared with healthy controls. Results of recent genetic and neuroimaging studies suggest a genetic contribution to the aetiology of Parkinson's disease and underline the interest in identifying preclinical signs of the disease. Methods-A battery of tests evaluating executive function was administered to 41 first degree relatives of patients with well documented familial Parkinson's disease and 39 healthy controls. A factorial discriminant analysis allowed isolation of a subgroup of 15 first degree relatives who could be considered as impaired compared with the healthy controls. Among these 15 "deviant" relatives, nine performed globally worse than the control subjects on all tasks. The six other subjects had mean or even high scores on all task variables, except on those highly correlated with the discriminant score of the factorial discriminant analysis. Results and conclusion-Among the first degree relatives of patients with familial Parkinson's disease, some manifested executive dysfunction comparable with that typically associated with the disease. Such impairment could represent a preclinical form of Parkinson's disease.
引用
收藏
页码:323 / 328
页数:6
相关论文
共 46 条
  • [1] [Anonymous], PARKINSONS DIS BEHAV
  • [2] DIFFERENTIAL BEHAVIORAL EFFECTS IN FRONTAL LOBE DISEASE
    BENTON, AL
    [J]. NEUROPSYCHOLOGIA, 1968, 6 (01) : 53 - &
  • [3] SOME TESTS OF THE DECAY THEORY OF IMMEDIATE MEMORY
    BROWN, J
    [J]. QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY, 1958, 10 (01): : 12 - 21
  • [4] BROWN RG, 1991, BRAIN, V114, P215
  • [5] INTERNAL VERSUS EXTERNAL CUES AND THE CONTROL OF ATTENTION IN PARKINSONS-DISEASE
    BROWN, RG
    MARSDEN, CD
    [J]. BRAIN, 1988, 111 : 323 - 345
  • [6] IMPAIRED PROBLEM-SOLVING IN PARKINSONS-DISEASE - IMPACT OF A SET-SHIFTING DEFICIT
    CRONINGOLOMB, A
    CORKIN, S
    GROWDON, JH
    [J]. NEUROPSYCHOLOGIA, 1994, 32 (05) : 579 - 593
  • [7] INTERPRETATION OF Z-SCORE ANTHROPOMETRIC INDICATORS DERIVED FROM THE INTERNATIONAL GROWTH REFERENCE
    DIBLEY, MJ
    STAEHLING, N
    NIEBURG, P
    TROWBRIDGE, FL
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1987, 46 (05) : 749 - 762
  • [8] DUBOIS B, 1994, REV NEUROL, V150, P763
  • [9] DUFFY JD, 1994, J NEUROPSYCH CLIN N, V6, P379
  • [10] AGING AND PARKINSONS-DISEASE - SUBSTANTIA-NIGRA REGIONAL SELECTIVITY
    FEARNLEY, JM
    LEES, AJ
    [J]. BRAIN, 1991, 114 : 2283 - 2301