Neocrotocembranal from Croton oblongifolius

被引：27

作者：

Roengsumran, S

Singtothong, P

Pudhom, K

Ngamrochanavanich, N

Petsom, A

Chaichantipyuth, C

机构：

[1] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand

[2] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Bangkok 10330, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 08期

关键词：

D O I：

10.1021/np9900268

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cembranoid diterpene, neocrotocembranal (3), was isolated from the stem bark of Croton oblongifolius. Its structure was established on the basis of spectroscopic analysis. This compound inhibited platelet aggregation induced by thrombin, with an IC50 value of 47.21 mu g/mL, and exhibited cytotoxicity against P-388 cells in vitro, with an IC50 value of 6.48 mu g/mL.

引用

收藏

页码：1163 / 1164

页数：2

相关论文

共 12 条

[1] STUDIES OF AUSTRALIAN SOFT CORALS .10. ISOLATION OF EPOXYISONEOCEMBRENE-A FROM SINULARIA-GRAYI AND ISONEOCEMBRENE-A FROM SARCOPHYTON-EHRENBERGI [J].

BOWDEN, BF ;

COLL, JC ;

HICKS, W ;

KAZLAUSKAS, R ;

MITCHELL, SJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (12) :2707-2712

[2]

CARMICHAEL J, 1987, CANCER RES, V47, P936

[3] STUDIES OF AUSTRALIAN SOFT CORALS .1. NEW CEMBRENOID DITERPENE FROM A SARCOPHYTON SPECIES [J].

COLL, JC ;

HAWES, GB ;

LIYANAGE, N ;

OBERHANSLI, W ;

WELLS, RJ .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1977, 30 (06) :1305-1309

[4]

LEVY GC, 1980, CARBON 13 NUCL MAGNE, P248

[5] A monogalactopyranosyl acylglycerol from Oltmannsiellopsis unicellularis (NIES-359) [J].

Rho, MC ;

Yasuda, K ;

Matsunaga, K ;

Ohizumi, Y .

PHYTOCHEMISTRY, 1997, 44 (08) :1507-1509

[6] ACTIVATION OF RABBIT PLATELETS BY CA2+ INFLUX AND THROMBOXANE A(2) RELEASE IN AN EXTERNAL CA2+-DEPENDENT MANNER BY ZOOXANTHELLATOXIN-A, A NOVEL POLYOL [J].

RHO, MC ;

NAKAHATA, N ;

NAKAMURA, H ;

MURAI, A ;

OHIZUMI, Y .

BRITISH JOURNAL OF PHARMACOLOGY, 1995, 115 (03) :433-440

[7] FURTHER BIOACTIVE CEMBRANOLIDE DITERPENES FROM THE GORGONIAN EUNICEA-SUCCINEA [J].

RODRIGUEZ, AD ;

DHASMANA, H .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (04) :564-570

[8] Two new cembranoids from Croton oblongifolius [J].

Roengsumran, S ;

Achayindee, S ;

Petsom, A ;

Pudhom, K ;

Singtothong, P ;

Surachetapan, C ;

Vilaivan, T .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (05) :652-654

[9] A STUDY OF SOME VARIABLES IN A TETRAZOLIUM DYE (MTT) BASED ASSAY FOR CELL-GROWTH AND CHEMOSENSITIVITY [J].

TWENTYMAN, PR ;

LUSCOMBE, M .

BRITISH JOURNAL OF CANCER, 1987, 56 (03) :279-285

[10] MARINE NATURAL-PRODUCTS - CEMBRENE-A AND CEMBRENE-C FROM A SOFT CORAL, NEPHTHEA SP [J].

VANDERAH, DJ ;

RUTLEDGE, N ;

SCHMITZ, FJ ;

CIERESZKO, LS .

JOURNAL OF ORGANIC CHEMISTRY, 1978, 43 (08) :1614-1616