Some p53-binding proteins that can function as arbiters of life and death

被引：75

作者：

Braithwaite, A. W.

Del Sal, G.

Lu, X.

机构：

[1] Univ Otago, Sch Med, Dept Pathol, Dunedin 9001, New Zealand

[2] Univ Trieste, LNCIB, Area Sci Pk, Trieste, Italy

[3] Univ Trieste, Dipartimento Biochim Biofis & Chim Macromol, I-34127 Trieste, Italy

[4] UCL Branch, Ludwig Inst Canc Res, London, England

来源：

CELL DEATH AND DIFFERENTIATION | 2006年 / 13卷 / 06期

关键词：

p53; E2F; ASPP; YB1; Pin1;

D O I：

10.1038/sj.cdd.4401924

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four sets of p53-binding proteins are discussed in this review. These are the E2F family, the ASPP family, Y-box-binding protein YB1, and the prolyl isomerase Pin1. Each appears to play a role in the decision by p53 to induce an arrest of cell proliferation or apoptosis and they may also be independent markers of cancer. Their activities appear to be linked with the cell cycle and they may also interact with each other. In this review, the properties of each protein class are discussed as well as how they affect p53 functions. A model is proposed as to how their activities might be coordinated.

引用

收藏

页码：984 / 993

页数：10

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