Timing the catch

被引：13

作者：

Mayer, MP ^{[1
]}

机构：

[1] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 01期

关键词：

D O I：

10.1038/nsmb0104-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mitochondrial 70 kDa heat shock protein (mtHsp70) drives the import of presequence-containing polypeptides into the matrix of mitochondria. A new essential component of the import motor was discovered that regulates the ATP hydrolysis activity of mtHsp70, thereby timing its binding to the incoming polypeptide chain.

引用

页码：6 / 8

页数：3

共 11 条

[1] J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix [J].

D'Silva, PD ;

Schilke, B ;

Walter, W ;

Andrew, A ;

Craig, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :13839-13844

[2] Regulated cycling of mitochondrial Hsp70 at the protein import channel [J].

Liu, QL ;

D'Silva, P ;

Walter, W ;

Marszalek, J ;

Craig, EA .

SCIENCE, 2003, 300 (5616) :139-141

[3]

Mayer MP, 2002, ADV PROTEIN CHEM, V59, P1

[4] The J-related segment of Tim44 is essential for cell viability: A mutant Tim44 remains in the mitochondrial import site, but inefficiently recruits mtHsp70 and impairs protein translocation [J].

Merlin, A ;

Voos, W ;

Maarse, AC ;

Meijer, M ;

Pfanner, N ;

Rassow, J .

JOURNAL OF CELL BIOLOGY, 1999, 145 (05) :961-972

[5] Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria [J].

Mokranjac, D ;

Sichting, M ;

Neupert, W ;

Hell, K .

EMBO JOURNAL, 2003, 22 (19) :4945-4956

[6] The TIM17•23 preprotein translocase of mitochondria:: composition transport into the matrix [J].

Moro, F ;

Sirrenberg, C ;

Schneider, HC ;

Neupert, W ;

Brunner, M .

EMBO JOURNAL, 1999, 18 (13) :3667-3675

[7] The protein import motor of mitochondria [J].

Neupert, W ;

Brunner, M .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (08) :555-565

[8] Versatility of the mitochondrial protein import machinery [J].

Pfanner, N ;

Geissler, A .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (05) :339-349

[9]

Ryan MT, 2002, ADV PROTEIN CHEM, V59, P223

[10] A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria [J].

Truscott, KN ;

Voos, W ;

Frazier, AE ;

Lind, M ;

Li, YF ;

Geissler, A ;

Dudek, J ;

Müller, H ;

Sickmann, A ;

Meyer, HE ;

Meisinger, C ;

Guiard, B ;

Rehling, P ;

Pfanner, N .

JOURNAL OF CELL BIOLOGY, 2003, 163 (04) :707-713

← 1 2 →