Development of a process for triazine-promoted amidation of carboxylic acids

被引：66

作者：

Rayle, HL ^{[1
]}

Fellmeth, L ^{[1
]}

机构：

[1] Rohm & Haas Co, Res Labs, Spring House, PA 19477 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1999年 / 3卷 / 03期

关键词：

D O I：

10.1021/op980097y

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A process has been developed for the triazine-promoted amidation of carboxylic acids, We have identified 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) as a cost-effective reagent for this transformation. The procedure is a suitable alternative to traditional amidation processes when an acid chloride cannot be prepared from the corresponding carboxylic acid due to safety, stability, or handling concerns.

引用

页码：172 / 176

页数：5

共 19 条

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