Oral squamous cell carcinomas stimulate osteoclast differentiation

被引：26

作者：

Deyama, Yoshiaki ^{[1
]}

Tei, Kanchu ^{[2
]}

Yoshimura, Yoshitaka ^{[1
]}

Izumiyama, Yuri ^{[2
]}

Takeyama, Sadaaki ^{[3
]}

Hatta, Mitsutoki ^{[1
]}

Totsuka, Yasunori ^{[2
]}

Suzuki, Kuniaki ^{[1
]}

机构：

[1] Hokkaido Univ, Dept Mol Cell Pharmacol, Grad Sch Dent Med, Kita Ku, Sapporo, Hokkaido 0608586, Japan

[2] Hokkaido Univ, Dept Oral & Maxillofacial Surg, Grad Sch Dent Med, Kita Ku, Sapporo, Hokkaido 0608586, Japan

[3] Tohoku Univ, Grad Sch Dent, Dept Oral Biol Dent Pharmacol, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

ONCOLOGY REPORTS | 2008年 / 20卷 / 03期

关键词：

oral cancer; bone invasion; osteoclast; parathyroid hormone-related protein;

D O I：

10.3892/or_00000057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Matrix metalloproteinases (MMPs) play important roles in the invasion and metastasis to soft tissues of carcinomas including, oral squamous cell carcinomas (SCCs). Although, osteoclastic bone resorption is an important step in bone involvement in a variety of malignancies, the mechanism of bone involvement of oral SCC remains unclear. Once cancer cells arrest in bone, the bone is a storehouse of a variety of cytokines and growth factors and thus provides an extremely fertile environment for cell growth. The bone-invasive oral cancer cell line, BHY, transcriptionally expressed detectable levels of TGF-ss, IL-Iss, IL-8, parathyroid hormone-related protein (PTHrP) and vascular endothelial growth factor (VEGF) mRNAs and failed to express GM-CSF, IL-6, and TNF-alpha. Furthermore, the BHY-conditioned medium greatly upregulated IL-6 and RANKL/ODF mRNA expression in osteoblasts, suggesting a potential indirect stimulation of osteoclastogenesis via the osteogenic lineage. Seven out of eleven patients with carcinomas of the lower alveolus and gingiva showing infiltrative bone involvement expressed PTHrP mRNA. These data suggest that the occurrence of PTHrP may be an indication of developing oral malignant carcinomas.

引用

页码：663 / 668

页数：6

共 28 条

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