Activating transcription factor 3 is a negative regulator of allergic pulmonary inflammation

被引：90

作者：

Gilchrist, Mark ^{[1
]}

Henderson, William R., Jr. ^{[2
]}

Clark, April E. ^{[1
]}

Simmons, Randi M. ^{[1
]}

Ye, Xin ^{[2
]}

Smith, Kelly D. ^{[3
]}

Aderem, Alan ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

[2] Univ Washington, Ctr Allergy & Inflammat, Dept Med, Seattle, WA 98109 USA

[3] Univ Washington, Dept Pathol, Seattle, WA 98109 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2008年 / 205卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1084/jem.20072254

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

We recently demonstrated the pivotal role of the transcription factor (TF) activating TF 3 (ATF3) in dampening inflammation. We demonstrate that ATF3 also ameliorates allergen-induced airway inflammation and hyperresponsiveness in a mouse model of human asthma. ATF3 expression was increased in the lungs of mice challenged with ovalbumin allergen, and this was associated with its recruitment to the promoters of genes encoding Th2-associated cytokines. ATF3-deficient mice developed significantly increased airway hyperresponsiveness, pulmonary eosinophilia, and enhanced chemokine and Th2 cytokine responses in lung tissue and in lung-derived CD4(+) lymphocytes. Although several TFs have been associated with enhanced inflammatory responses in the lung, ATF3 attenuates the inflammatory responses associated with allergic airway disease.

引用

页码：2349 / 2357

页数：9

共 41 条

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